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To facilitate comparison across preclinical studies and assess translational potential, Table 3 summarizes the principal experimental parameters reported in representative in vivo models, including animal species, dosing, treatment duration, and observed endpoints
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Discussion In a population of patients with type 2 diabetes who had no prior diagnosis of eye diseases, this cohort study found that semaglutide or tirzepatide compared with other antidiabetic medications was associated with a differential risk of optic nerve and visual pathways, including increased risk of NAION and other optic nerve disorders, but not optic neuritis, papilledema, optic atrophy, or optic disc orders
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